67 NCCN Guidelines for Patients ® : Multiple Myeloma, 2019 Words to know regimen A treatment plan that specifies the dose, schedule, and duration of treatment. relapse The return of myeloma signs or symptoms after a period of improvement. sedative A drug that helps a person to relax or go to sleep. serum free light chain assay A blood test that measures the amount of the shorter fragments of the proteins made by myeloma cells. serum immunofixation electrophoresis (SIFE) A test used to identify the type of M-proteins in the blood. serum protein electrophoresis (SPEP) A test that measures the amount of M-proteins in the blood. serum quantitative immunoglobulins A test that measures the amount of each type of antibody in the blood. serum viscosity A test that measures the thickness of blood. side effect An unhealthy or unpleasant physical or emotional response to treatment. SIFE serum immunofixation electrophoresis smoldering (asymptomatic) myeloma Myeloma that isn’t causing symptoms or damaging organs. solitary plasmacytoma Cancer that is one mass of myeloma cells—abnormal plasma cells that grow and divide all the time making too many copies of themselves. SPEP serum protein electrophoresis spine The bones, muscles, and other tissues along the back from the base of the skull to the tailbone. stable disease Cancer that is not getting worse or better in terms of extent or severity. stem cell transplant Treatment that uses chemotherapy to destroy cells in the bone marrow and then replaces them with healthy blood stem cells. steroid A drug used to reduce swelling, redness, and pain, but also to kill myeloma cells. supportive care Treatment for symptoms of cancer or side effects of cancer treatment. surgeon A doctor who’s an expert in operations to remove or repair a part of the body. surgery An operation to remove or repair a part of the body. symptom A physical or mental problem a person experiences that may indicate a certain disease or health condition. systemic therapy Drugs used to treat cancer cells throughout the body. tandem stem cell transplant Treatment in which a planned second round of high-dose chemotherapy and autologous stem cell transplant are given within 6 months of the first transplant. targeted therapy Treatment with drugs that target a specific or unique feature of cancer cells. tissue biopsy Removal of a small amount of tissue from the body to test for disease. total protein (urine) A test that measures the amount and type of protein in urine collected over a 24-hour period. transfusion Replacing lost blood with new blood. treatment response An outcome or improvement caused by treatment. tumor burden The amount or extent of cancer in the body.