NCCN Guidelines for Patients® | Diffuse Large B-cell Lymphoma

9 NCCN Guidelines for Patients ® : Diffuse Large B-cell Lymphoma, 2017 1 DLBCL basics A disease of cells In the United States most non-Hodgkin’s lymphomas—85 out of every 100—are B-cell lymphomas. About 10 out of 100 are T-cell lymphomas. A few have unknown cell origin. It is now known that most Hodgkin lymphomas are also from B-cells. Thus, Hodgkin and non-Hodgkin’s lymphomas are more related than first thought. Diffuse large B-cell lymphoma DLBCL is a type of non-Hodgkin’s lymphoma. It is a cancer of B-cells. There are many types of B-cells and, thus, many B-cell cancers. B-cells differ from one another based on the cell’s stage of development. As B-cells “mature” they change in their ability to make antibodies. Antibodies are Y-shaped proteins that are made in response to the presence of antigens. Some antigens enter your body from outside. Such antigens include viruses, bacteria, chemicals, and pollen. Some antigens are formed inside your body like those found on tissue cells. Antibodies attach to antigens, which triggers a response from your immune system. Cell of origin DLBCL is a cancer of B-cells that have been exposed to antigens. Some DLBCLs start from B-cells that are within the “factories” of your lymphatic organs. These factories are called germinal centers. Germinal centers are short-lived structures that are formed in response to an outside antigen. B-cells undergo changes within the germinal centers to prepare them for making antibodies. Other DLBCLs start from B-cells that have been released from germinal centers. Figure 1 Lymphatic system The lymphatic system kills germs in the body and collects and transports lymph to the bloodstream. Illustration Copyright © 2017 Nucleus Medical Media, All rights reserved.