NCCN Guidelines for Patients® | Diffuse Large B-cell Lymphoma

30 NCCN Guidelines for Patients ® : Diffuse Large B-cell Lymphoma, 2017 3 Overview of cancer treatments Steroids | Targeted therapy Steroids Steroid is the short name for corticosteroid. It is a type of drug that is often used to relieve inflammation. Steroids also are toxic to lymphoma cells. They have strong anti-cancer effects. The steroids used to treat DLBCL are listed in Guide 3 . Steroids are a part of some chemotherapy regimens. They are often given on the same days as chemotherapy but only for a few days or a week. Prednisone is made in pill form but dexamethasone and methylprednisolone are made both as a liquid to be injected or a pill to be swallowed. Most side effects of steroids fade away once the drugs are stopped. Common side effects include feeling hungry, upset stomach, and mood changes. You may have trouble sleeping. Wounds may be slow to heal. Swelling of ankles, feet, or hands is also common. Targeted therapy Targeted therapy is a class of drugs. These drugs work on molecules that help cancer cells grow. They are less likely to harm normal cells than chemotherapy. Targeted therapy for DLBCL is called brentuximab vedotin. On the surface of some DLBCL cells are proteins called CD30. Brentuximab consists of a human- made monoclonal antibody, which attaches to CD30. After attaching, it enters the cells. Then, it releases chemotherapy. By targeting only cells with CD30, fewer normal cells are harmed. Brentuximab vedotin is a treatment option for refractory or relapsed DLBCL that is 1) CD30 positive and 2) won’t be treated with a blood stem cell transplant. Read Part 4 for more information. Brentuximab vedotin is sold as Adcetris ® . It is slowly injected into a vein for about 30 minutes. It is often given every 3 weeks. The most common side effects include tingling in hands and feet, fatigue, nausea, diarrhea, fever, rash, and lung infections. Blood cell counts may decrease. Rare but severe effects include brain infection, serious disorder of skin and mucous membranes, and kidney problems. Not all side effects of brentuximab vedotin are listed here. Please ask your treatment team for a complete list. If a side effect bothers you, tell your treatment team. There may be ways to help you feel better. There are also ways to prevent some side effects. Guide 3. Steroids Generic (chemical) name Brand name (sold as) Dexamethasone – Methylprednisolone; Methylprednisolone acetate; Methylprednisolone sodium succinate A-Methapred Depo-Medrol ® Medrol ® Solu-Medrol ® Prednisone –

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