NCCN Guidelines for Patients® | Diffuse Large B-cell Lymphoma
56 NCCN Guidelines for Patients ® : Diffuse Large B-cell Lymphoma, 2017 Dictionary double-hit lymphoma The presence of a MYC gene rearrangement with either a BCL2 or BCL6 gene rearrangement. echocardiogram A test that uses sound waves to make pictures of the heart. external beam radiation therapy (EBRT) Treatment with radiation that is delivered by a machine into the body. fatigue Severe tiredness despite getting enough sleep that limits one’s ability to function. fertility specialist An expert who helps men and women have babies. flow cytometry A test that looks at certain substances on the surface of cells to identify the type of cells present. fluorescence in situ hybridization (FISH) A lab test that uses special dyes to look for abnormal chromosomes. four-dimensional computed tomography (4D-CT) A CT scan that can show the movement of organs. gene Instructions in cells for making and controlling cells. gene rearrangement The fusion of parts from two genes that creates a new gene. general anesthesia A controlled loss of wakefulness from drugs. germinal center A short-lived structure that forms within an lymphatic organ in response to germs. germinal center B-cell (GCB) A type of lymphocyte found within short-lived structures, called germinal centers, within lymphatic organs. human leukocyte antigen (HLA) typing A blood test that finds a person’s unique set of proteins on cells. image-guided radiation therapy (IGRT) Radiation therapy that uses imaging tests during treatment to better target the tumor. imaging test A test that makes pictures (images) of the inside of the body. immune system The body’s natural defense against illness. immunohistochemistry (IHC) A test of cancer cells to find specific cell traits involved in abnormal cell growth. immunomodulator A type of drug that modifies some parts of the body’s disease-fighting system. intensity-modulated radiation therapy (IMRT) Radiation therapy that uses small beams of different strengths based on the thickness of the tissue. International Prognostic Index (IPI) A scoring system used to predict the outcome of diffuse large B-cell lymphoma. involved-site radiation therapy (ISRT) Treatment with high-energy rays (radiation) that is delivered to lymph nodes and nearby sites with cancer. karyotype A test that uses a microscope to examine a cell’s chromosomes. kidney One of a pair of organs that removes waste from blood, helps control blood pressure, and helps to make red blood cells. lactate dehydrogenase A protein that helps to make energy in cells. liver Organ that removes waste from the blood and helps to digest food. local anesthesia A controlled loss of feeling in a small area of the body caused by drugs. lumbar puncture A procedure in which a thin needle is inserted between the bones of the spine to remove a sample of spinal fluid or give drugs into the spinal fluid. lymph A clear fluid containing white blood cells.