NCCN Guidelines for Patients® | Follicular Lymphoma Grade 1-2

9 NCCN Guidelines for Patients ® : Follicular Lymphoma, Grade 1–2, 2017 1 Follicular lymphoma basics A disease of cells Most non-Hodgkin’s lymphomas—85 out of every 100—are B-cell lymphomas. About 10 out of 100 are T-cell lymphomas. A few have unknown cell origin. It is now known that most Hodgkin lymphomas are also from B-cells. Thus, Hodgkin and non-Hodgkin’s lymphomas are more related than first thought. Follicular lymphoma Follicular lymphoma is a type of non-Hodgkin’s lymphoma. It is a cancer of B-cells. There are many types of B-cells and, thus, many B-cell cancers. B-cells differ from one another based on the cell’s stage of development. As B-cells “mature” they change in their ability to make antibodies. Antibodies are Y-shaped proteins that are made in response to the presence of antigens. Some antigens enter your body from outside. Such antigens include viruses, bacteria, chemicals, and pollen. Some antigens are formed inside your body like those found on tissue cells. Antibodies attach to antigens, which triggers a response from your immune system. Germinal centers Follicular lymphoma is a cancer of B-cells that are within the “factories” of your lymphatic organs. These factories are called germinal centers. Germinal centers are short-lived structures. They form in response to an outside antigen. Germinal centers have a dark and light zone. In the dark zone, B-cells increase in number. At this stage, B-cells are called centroblasts. After multiplying, B-cells enter the light zone and undergo a number of normal changes to make antibodies. B-cells in the light zone are called centrocytes. Figure 1 Lymphatic system The lymphatic system kills germs in the body and collects and transports lymph to the bloodstream. Illustration Copyright © 2017 Nucleus Medical Media, All rights reserved.