NCCN Guidelines for Patients® | Follicular Lymphoma Grade 1-2

24 NCCN Guidelines for Patients ® : Follicular Lymphoma, Grade 1–2, 2017 3 Overview of cancer treatments Immunotherapy In Part 3, the main treatment types for follicular lymphoma are briefly described. Knowing what a treatment is will help you understand your treatment options listed in Part 4. There is more than one treatment for follicular lymphoma. Not every person will receive every treatment described in this chapter. Immunotherapy The immune system is your body’s natural defense against disease. Immunotherapy increases the activity of this system. As a result, it improves your body’s ability to find and destroy cancer cells. Immunotherapy is a common treatment for follicular lymphoma. Immunotherapy for follicular lymphoma uses anti-CD20 monoclonal antibodies. These human- made antibodies attach to CD20 on the surface of lymphoma cells. See Figure 7 . They work by marking the cells for destruction. They may directly kill cells, too. There are two anti-CD20 monoclonal antibodies for follicular lymphoma. Both are briefly described next. Ask your treatment team for a full list of common and rare side effects. Figure 7 Anti-CD20 monoclonal antibody Anti-CD20 monoclonal antibodies attach to lymphoma cells to mark them for destruction by your immune system. Derivative work of Rituximab Binding to CD20 on a B Cell Surface by NIAID available at commons. Rituxima_Binding_to_CD20_on_a_B_Cell_Surface_(6830897205).jpg under a Creative Commons Attribution 2.0 Generic license