NCCN Guidelines for Patients® | Mantle Cell Lymphoma

8 NCCN Guidelines for Patients ® : Mantle Cell Lymphoma, 2019 1  MCL basics A disease of cells lymph nodes throughout your body. See Figure 1 . High numbers of lymph nodes exist in the middle of your chest, neck, armpit, groin, pelvis, and along your gut. Other lymphoid tissues include the spleen, tonsils, and thymus. The spleen filters and kills germs in blood. Tonsils kill germs in lymph that enter through your mouth and nose. In children, the thymus stores T cells until they are able to fight germs. There are also small clumps of lymphoid tissue in your gut, thyroid, breasts, lungs, eyes, and skin. A disease of cells Your body is made of trillions of cells. Cancer is a disease of cells. There are many types of cells, so there are many types of cancers. Despite many types, all cancers share some common features. More research is needed to learn how cancers begin and worsen over time. Lymphoma Each type of cancer is named after the normal cell from which it formed. Lymphoma is a cancer of lymphocytes within the lymph system. There are two main types of lymphomas. Hodgkin lymphoma is defined by the presence of Reed-Sternberg or related cells. Non-Hodgkin’s lymphomas include all the other types of lymphomas. Mantle cell lymphoma MCL is a type of non-Hodgkin’s lymphoma. It is a cancer of B cells. There are many types of B cells and, thus, many B-cell cancers. MCL is named for the B cells from mantle zones within lymph nodes. Most cases of MCL form from these B cells. Cancer cells When needed, normal cells grow and then divide to make new cells. When old or damaged, they die. Normal cells also stay in place. Cancer cells don’t behave like normal cells. They make new cells that aren’t needed. They die slowly Figure 1 Lymph system The lymph (or lymphatic) system kills germs in the body and collects and transports lymph to the bloodstream. Illustration Copyright © 2019 Nucleus Medical Media, All rights reserved.