NCCN Guidelines for Patients® | Mantle Cell Lymphoma

9 NCCN Guidelines for Patients ® : Mantle Cell Lymphoma, 2017 1 Mantle cell lymphoma basics A disease of cells Most non-Hodgkin’s lymphomas—85 out of every 100—are B-cell lymphomas. About 10 out of 100 are T-cell lymphomas. A few have unknown cell origin. It is now known that most Hodgkin lymphomas are also from B-cells. Thus, Hodgkin and non-Hodgkin’s lymphomas are more related than first thought. Mantle cell lymphoma Mantle cell lymphoma is a type of non-Hodgkin’s lymphoma. It is a cancer of B-cells. There are many types of B-cells and, thus, many B-cell cancers. B-cells differ from one another based on the cell’s stage of development. As B-cells “mature” they change in their ability to make antibodies. Antibodies are Y-shaped proteins that are made in response to the presence of antigens. Some antigens enter your body from outside. Such antigens include viruses, bacteria, chemicals, and pollen. Some antigens are formed inside your body like those found on tissue cells. Antibodies attach to antigens, which triggers a response from your immune system. Naïve B-cells Germinal centers are short-lived structures within lymph nodes. They form in response to an outside antigen. Within germinal centers, B-cells undergo changes to prepare them for making antibodies. Most mantle cell lymphomas start from B-cells that have not passed through a germinal center. These “naïve” B-cells can be found in mantle zones that surround germinal centers. Of interest, a subset of mantle cell lymphomas appears to start from B-cells that have passed through germinal centers. Figure 1 Lymphatic system The lymphatic system kills germs in the body and collects and transports lymph to the bloodstream. Illustration Copyright © 2017 Nucleus Medical Media, All rights reserved.