NCCN Guidelines for Patients® | Mantle Cell Lymphoma

11 NCCN Guidelines for Patients ® : Mantle Cell Lymphoma, 2019 1  MCL basics Tests for MCL An immunohistochemistry (IHC) panel can be used to assess for BCL2, BCL6, CD3, CD5, CD10, CD20, CD21, CD23, cyclin D1, Ki-67, and TP53. Sometimes, it is helpful to include LEF1 and SOX11 in the panel. Flow cytometry may be done, too. If done, it should test for CD5, CD10, CD19, CD20, CD23, and kappa and lambda light chain proteins. It may be helpful to also test for CD200. Genetic tests MCL has common abnormal changes in chromosomes and genes. At times, it may help to test for certain changes. The results can be used for diagnosis and prognosis. Prognosis is the expected outcome of the cancer. A translocation is a switching of parts between two chromosomes. Your doctor may want to test for a translocation between chromosomes 11 and 14. See Figure 4 . Karyotype and fluorescence in situ hybridization (FISH) are lab tests used to assess chromosomes. Mutations are abnormal changes in genes. Certain mutations are known to affect prognosis. At times, it may be useful to test for IGHV or TP53 mutations. DNA sequencing is the name of the lab test used to assess for mutations in genes. Pathology report Lab results used for diagnosis are included in a pathology report. This report will be sent to your doctor. Ask for a copy. Your doctor will review the results with you. Take notes and ask questions. Figure 4 Translocation A translocation is a switching of parts between chromosomes. In mantle cell lymphoma cells, a translocation between chromosomes 11 and 14 is often present. The result is too much cyclin D1 on the surface of cancer cells. Copyright © 2019 National Comprehensive Cancer Network ® (NCCN ® ). www.nccn.org

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