NCCN Guidelines for Patients® | Mantle Cell Lymphoma

14 NCCN Guidelines for Patients ® : Mantle Cell Lymphoma, 2017 1 Mantle cell lymphoma basics Review Tests that detect translocations are a karyotype or FISH ( f luorescence i n s itu h ybridization). IGHV mutations or SOX11 Some mantle cell lymphomas have mutations in the IGHV ( i mmunoglobulin h eavy-chain v ariable) region genes. These lymphomas appear to have started from B-cells that have passed through germinal centers. They often have low or absent SOX11 levels. It may be useful to test for IGHV mutations since they are a sign of slow-growing mantle cell lymphoma. DNA sequencing is a lab test of blood or marrow that is used to look for mutations in genes. This test reveals the order of the chemicals that make up DNA. Other genetic errors Other genetic tests may be useful if the type of cancer is unclear. A karyotype or FISH to test for translocation of chromosomes 14 and 18 may be done. This translocation is often found in follicular lymphoma and sometimes diffuse large B-cell lymphoma. If present, the cancer is unlikely mantle cell lymphoma. Likewise, the cancer is likely to be chronic lymphocytic leukemia if a FISH panel shows defects in chromosomes 11, 12, 13, or 17. Pathology report All lab results are recorded in a pathology report. A report will be written each time tissue is removed from your body and tested. These reports are vital to diagnosis and planning treatment. Review your pathology report(s) with your doctor. Ask questions if you don’t understand. This information can be complex. It’s also a good idea to get a copy of your pathology report(s) and take notes. Review † † The lymphatic system consists of lymph and a network of vessels and organs. It helps kill germs in the body and transports fluids to the bloodstream. † † Lymphomas are cancers that start in lymphocytes within the lymphatic system. Mantle cell lymphoma is a cancer of B-cells. It starts in B-cells that are from germinal centers found within lymphatic organs. † † Incisional or excisional biopsy is needed to diagnose mantle cell lymphoma. † † Most mantle cell lymphomas grow and spread moderately fast. However, some do grow slowly and others very fast. † † The biopsy tissue should be tested by a hematopathologist. The hematopathologist will perform a number of tests that assess for cell type, surface proteins, and maybe genetics.

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