NCCN Guidelines for Patients® | Mantle Cell Lymphoma

14 NCCN Guidelines for Patients ® : Mantle Cell Lymphoma, 2019 1  MCL basics Review from being made. MCL that is limited in extent may be treated with involved-site radiation therapy (ISRT). For MCL that returns after treatment (relapse), radiation may be also be used. Stem cell transplant This treatment is also called a hematopoietic cell transplant. It replaces damaged or destroyed stem cells with healthy stem cells. The healthy stem cells form new bone marrow and blood cells. There are two types of transplants. An autologous transplant is also called high-dose therapy with autologous stem cell rescue (HDT/ ASCR). First, your healthy stem cells will be removed. You will then receive chemotherapy to kill the cancer cells. It will also kill the blood-producing cells in the bone marrow. Your healthy stem cells will then be returned to “rescue” your bone marrow. An allogeneic transplant uses healthy stem cells from a donor. You’ll first receive treatment called conditioning to kill your bone marrow cells. Next, you’ll receive the donor cells. These cells will form new, healthy bone marrow. They will also attack cancer cells that weren’t killed by prior treatment. Review † † The lymph system consists of lymph and a network of vessels and organs. It helps kill germs in the body and transports fluids to the bloodstream. † † Lymphomas are cancers of lymphocytes within the lymph system. MCL is a cancer of lymphocytes called B cells. It often forms in B cells from the mantle zones of lymph nodes. † † An incisional or excisional biopsy is needed to diagnose B-cell lymphoma. † † Biopsy samples should be tested by a hematopathologist. The hematopathologist will perform a number of tests that assess for cell type, surface proteins, and maybe genetics. † † Clinical trials give people access to new tests and treatments that they otherwise couldn’t have received. † † There are many types of treatments for MCL, including chemotherapy, corticosteroids, antibody treatment, targeted therapy, immunomodulators, radiation therapy, and stem cell transplant. Maintaining a positive attitude is important. Reach out to your family and friends for support.” – Scott Husband and survivor “

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