NCCN Guidelines for Patients® | Mantle Cell Lymphoma

19 NCCN Guidelines for Patients ® : Mantle Cell Lymphoma, 2019 2  Treatment planning Biopsies | Heart tests Whole-body PET/CT CT can be combined with PET (positron emission tomography). This imaging is called a PET/CT scan. PET shows how your cells are using a simple form of sugar (glucose). Contrast should be used with CT. Whole-body PET/CT may be given in addition to or instead of CT. It can show the presence of cancer when other tests do not. PET/CT is also used to assess if treatment is working. Biopsies MCL can spread outside the lymph system. It is often but not always found in bone marrow at diagnosis. It commonly spreads to the gut (GI tract). Rarely, it spreads into spinal (or cerebrospinal) fluid. As such, you may have one or more of the following procedures. Bone marrow biopsies A bone marrow biopsy removes a core of bone. The bone sample will be sent a lab for cancer testing. You may also have a bone marrow aspiration, which removes liquid bone marrow. Both procedures may be done at the same time. GI biopsies Endoscopy and colonoscopy are procedures that allow doctors to see inside the GI tract. Samples of tissue that may have cancer will be removed and tested. A device called an endoscope is used in the upper GI tract. A device called a colonoscope is used in the lower GI tract. These procedures are needed to confirm early-stage cancer. Lumbar puncture A lumbar puncture is a procedure that removes spinal fluid. It is also called a spinal tap. Your doctor may suspect that the cancer is in spinal fluid based on symptoms or the cancer type. Heart tests Some cancer treatments can damage your heart. To plan treatment, your doctor may test how well your heart pumps blood. You may get an echocardiogram or multigated acquisition (MUGA) scan. An echocardiogram uses sound waves to make pictures of your heart. A MUGA scan makes pictures using a radiotracer and special camera. My initial symptom was an enlarged spleen. A bone marrow biopsy determined I had mantle cell lymphoma. It is a good thing my primary care doctor found the enlarged spleen because I did not have any of the usual symptoms.” – Scott Survivor, diagnosed at age 54 “

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