NCCN Guidelines for Patients® | Mantle Cell Lymphoma

26 NCCN Guidelines for Patients ® : Mantle Cell Lymphoma, 2017 3 Overview of cancer treatments Immunomodulators after the first dose of rituximab by infusion. Also, injections may be an option as long as rituximab isn’t being used with ibritumomab tiuxetan. Injections last between 5 and 7 minutes. Side effects are unhealthy or unpleasant physical or emotional responses to treatment. Ask your treatment team for a full list of common and rare side effects. You may have an allergic reaction while receiving rituximab. Other common side effects are chills, infections, body aches, tiredness, and low blood cell counts. Rituximab also increases your chances for tumor lysis syndrome, heart problems, and blockage and tears in your gut. Immunomodulators Immunomodulators are drugs that modify different parts of the immune system. Lenalidomide (Revlimid ® ) is an immunomodulator. It is received with rituximab as a first-line treatment. For second- line treatment, rituximab or rituximab with ibrutinib may be added. Lenalidomide treats lymphoma in more than one way. As an immunomodulator, it boosts the immune system. It also helps stop cancer cells from increasing in number. Third, it also works like a type of targeted therapy called an angiogenesis inhibitor. Angiogenesis inhibitors stop the growth of new blood vessels that would provide food (nutrients) to the cancer. Lenalidomide is made in pill form. It is given in cycles of treatment days followed by days of rest. A cycle may consist of 3 weeks of treatment and 1 week of rest. It may also be given for 4 straight weeks. Cycles may repeat until the cancer grows or side effects become severe. Common side effects include low blood counts, diarrhea, itching, rash, and fatigue. Serious but less common side effects include blood clots, bleeding disorders, loss of vision, and skin cancer. Ask your treatment team for a full list of side effects. Maintaining a positive attitude is important. Reach out to your family and friends for support. – Scott Husband and survivor “