NCCN Guidelines for Patients® | Mantle Cell Lymphoma

33 NCCN Guidelines for Patients ® : Mantle Cell Lymphoma, 2017 Blood stem cell transplant Blood (hematopoietic) stem cells are cells from which all blood cells are formed. They mainly exist in bone marrow. Cancer or its treatment can damage or destroy blood stem cells. A blood stem cell transplant replaces damaged or destroyed stem cells with healthy stem cells. The healthy stem cells form new marrow and blood cells. A transplant is sometimes an option for advanced mantle cell lymphoma. There are two types of blood stem cell transplants. Autologous blood stem cell transplant Autologous blood stem cell transplant uses your healthy stem cells to repair bone marrow. This treatment is also called HDT/ASCR ( h igh- d ose t herapy with a utologous s tem c ell r escue). Your healthy stem cells will be collected when imaging tests show that cancer treatment is working. You will then receive intense chemotherapy and maybe radiation to destroy any remaining cancer cells. This intense treatment will also destroy bone marrow. Your healthy stem cells will be put back into your body to “rescue” your marrow. Allogeneic blood stem cell transplant Allogeneic blood stem cell transplant uses healthy stem cells from a donor. HLA ( h uman l eukocyte a ntigen) typing is the test used to check if the donor and your tissue type are a good fit. Chemotherapy will be given to destroy cancer cells and suppress your immune system from attacking the donor cells. The transplanted stem cells will form new marrow and attack remaining cancer cells. This attack is known as the GVT ( g raft- v ersus- t umor) effect. On the other hand, there is a serious risk of GVHD ( g raft- v ersus- h ost d isease). GVHD is when the donated cells see the cells in your body as foreign and attack them. Complementary and alternative medicine CAM ( c omplementary and a lternative m edicine) is a group of treatments that aren’t often given by doctors. There is much interest today in CAM for cancer. Many CAMs are being studied to see if they are truly helpful. Complementary medicines are treatments given along with usual medical treatments. While CAMs aren’t known to kill cancer cells, they may improve your comfort and well- being. Two examples are acupuncture for pain management and yoga for relaxation. Alternative medicine is used in place of usual medicine. Some alternative medicines are sold as cures even though they haven’t been proven to work in clinical trials. If there was good proof that CAMs or other treatments cured cancer, they would be included in this book. It is important to tell your treatment team if you are using any CAMs. They can tell you which CAMs may be helpful and which CAMs may limit how well medical treatments work. 3 Overview of cancer treatments Blood stem cell transplant