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NCCN Guidelines for Patients


Mycosis Fungoides, Version 1.2016


Overview of cancer treatments Review


• Steroids have anti-cancer effects and are

often applied directly to skin lesions.

• Retinoids stop some types of cancer cells

from growing. Some retinoids are applied

directly to the skin while others are pills that

can treat cancer anywhere in the body.

• HDAC inhibitors enter cancer cells and turn

genes back on to cause cell death.

• Monoclonal antibodies for mycosis fungoides

attach to the lymphoma cells to 1) trigger an

attack from your immune system, or 2) deliver


• Immunotherapy for mycosis fungoides

includes medicines that are human-made

copies of molecules from your immune

system. Another medicine triggers your body

to make these molecules.

• Chemotherapy stops the life cycle of cancer


• Electron radiation therapy treats skin lesions

without much, if any, damage to underlying

tissue. There are two approaches—local and

total skin electron beam therapy.

• Phototherapy uses ultraviolet radiation to treat

local skin lesions.

• Extracorporeal photopheresis uses ultraviolet

radiation to treat cancer throughout the body.

• An allogeneic transplant suppresses your

immune system then transfuses donor stem

cells that will attack cancer cells.

• Clinical trials give people access to new tests

and treatments that otherwise can’t usually

be received. These new tests and treatments

may be approved, in time, by the FDA.