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NCCN Guidelines for Patients


Mycosis Fungoides, Version 1.2016



Genetic counseling | Treatment


Treatment guide

Stage IA treatment

Chart 4.1.1

lists treatment options for stage IA

cancers. Treatments that are directly given to skin

lesions work very well. However, such treatments

may work less well for folliculotropic and large-cell

transformed subtypes. Some research suggests that

treatment for stage III cancer works better for stage IA

cancers with blood involvement, but more research is


One or more treatments may be used to treat

stage IA cancers. Options for topical treatment include

steroids, mechlorethamine, bexarotene, tazarotene,

and imiquimod. Radiation therapy and phototherapy

are options, too. Radiation treats a single lesion of

mycosis fungoides very well. If treatment works, you

may stay on your treatment for a while or slowly stop

treatment to prolong the good results.

Start skin treatment again if the cancer was fully

treated but came back as stage IA. In this case, you

may receive the same treatment as before or a new

treatment. People often have good results with the

same treatment. If one or two courses of local skin

treatment didn’t work well, try another treatment listed

in the chart.

You may have already tried multiple courses of

local skin treatment without much change. Despite

treatment, the cancer may be worse. In either case,

options are listed in Chart 4.1.2.

Chart 4.1.2

lists second-line options for cancers that

were stage IA at diagnosis. There are three options.

One or more systemic treatments with or without

generalized skin treatment is one option. Another

option is total skin electron beam therapy. A third

option is to join a clinical trial.