NCCN Guidelines for Patients
Mycosis Fungoides, Version 1.2016
Genetic counseling | Treatment
Stage IA treatment
lists treatment options for stage IA
cancers. Treatments that are directly given to skin
lesions work very well. However, such treatments
may work less well for folliculotropic and large-cell
transformed subtypes. Some research suggests that
treatment for stage III cancer works better for stage IA
cancers with blood involvement, but more research is
One or more treatments may be used to treat
stage IA cancers. Options for topical treatment include
steroids, mechlorethamine, bexarotene, tazarotene,
and imiquimod. Radiation therapy and phototherapy
are options, too. Radiation treats a single lesion of
mycosis fungoides very well. If treatment works, you
may stay on your treatment for a while or slowly stop
treatment to prolong the good results.
Start skin treatment again if the cancer was fully
treated but came back as stage IA. In this case, you
may receive the same treatment as before or a new
treatment. People often have good results with the
same treatment. If one or two courses of local skin
treatment didn’t work well, try another treatment listed
in the chart.
You may have already tried multiple courses of
local skin treatment without much change. Despite
treatment, the cancer may be worse. In either case,
options are listed in Chart 4.1.2.
lists second-line options for cancers that
were stage IA at diagnosis. There are three options.
One or more systemic treatments with or without
generalized skin treatment is one option. Another
option is total skin electron beam therapy. A third
option is to join a clinical trial.