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48

NCCN Guidelines for Patients

®

Mycosis Fungoides, Version 1.2016

3

DCIS

Genetic counseling | Treatment

4

Treatment guide

Stage III treatment

4.4 Stage III treatment

See second- and third-line treatments, page 50.

Þ

Start with first-line treatments:

Œ

Try another course of

first-line treatments if:

• Treatment worked at

first but the cancer

came back as stage I,

II, or III, or

• Only 1 or 2 treatments

were tried and didn’t

work

Chart 4.4.1 First-line treatments

No blood Involvement

• Topical steroids

• Topical chemotherapy (ie, mechlorethamine)

• Phototherapy

• Total skin electron beam therapy

Blood involvement

• Systemic treatment ± skin treatment

Systemic treatment

◦◦ Oral retinoids

◦◦ Interferons

◦◦ HDAC inhibitors (ie, belinostat,vorinostat, romidepsin)

◦◦ Extracorporeal photopheresis

◦◦ Methotrexate

Skin treatment

◦◦ Topical steroids

◦◦ Mechlorethamine

◦◦ Local radiation

◦◦ Topical retinoids

◦◦ Phototherapy

◦◦ Topical imiquimod

◦◦ Total skin electron beam therapy