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52

NCCN Guidelines for Patients

®

Mycosis Fungoides, Version 1.2016

3

DCIS

Genetic counseling | Treatment

4

Treatment guide

Stage IV treatment

4.5 Stage IV treatment

Start with first-line treatments:

Œ

Ü

Try another course of

first-line treatments if:

• Treatment worked at

first but the cancer

came back, or

• Only 1 or 2 treatments

were tried and didn’t

work

Join a clinical trial if:

• Multiple courses of treatment didn’t work, or

• The cancer is worse

Chart 4.5.1 First-line treatments

Treatment options

• Single-agent systemic treatment ± radiation therapy

Cancer growth is not fast

◦◦ Brentuximab vedotin

◦◦ Liposomal doxorubicin

◦◦ Gemcitabine

◦◦ Low-dose pralatrexate

◦◦ Chlorambucil

◦◦ Pentostatin

◦◦ Etoposide

◦◦ Cyclophosphamide

◦◦ Temozolomide

◦◦ Low-dose methotrexate

◦◦ Bortezomib

Cancer growth is fast

◦◦ Bortezomib

◦◦ Brentuximab vedotin

◦◦ Gemcitabine

◦◦ Liposomal doxorubicin

◦◦ Low- or standard-dose pralatrexate

◦◦ Romidepsin

• Multi-agent chemotherapy ± radiation therapy