NCCN Guidelines for Patients
Mycosis Fungoides, Version 1.2016
Genetic counseling | Treatment
• Treatment for mycosis fungoides partly
depends on the stage of cancer.
• You will likely receive multiple courses of first-
line treatments before moving on to second-
line treatments, if needed.
• Local skin treatments are often first used to
treat stage IA cancers. Second-line treatments
include systemic treatments and total skin
electron beam therapy.
• Generalized skin treatments are often first
used to treat stage IB and IIA cancers.
Second-line treatments include systemic
treatments and combination treatments.
• Local radiation therapy for skin tumors and
skin treatments for other lesions are first used
to treat limited stage IIB cancers. Second-
line treatments include total skin electron
beam therapy, systemic treatments, and
• Total skin electron beam therapy, systemic
treatment with or without skin treatment, and
combination treatment are first used to treat
generalized stage IIB cancers. Second-line
treatments include multi-agent chemotherapy
and allogeneic stem cell transplant.
• Stage III first-line treatment depends on
whether there is blood involvement. If not,
skin treatments may be received. Systemic
treatment with or without skin treatment
is used if there is blood involvement.
Second-line treatments are combinations of
systemic treatments or systemic with skin
treatments. Third-line treatments include
systemic treatments, alemtuzumab, and
nonmyeloablative allogeneic transplant.
• Single-agent or multi-agent systemic
treatments are used to treat stage IV cancers.