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54

NCCN Guidelines for Patients

®

Mycosis Fungoides, Version 1.2016

3

DCIS

Genetic counseling | Treatment

4

Treatment guide

Review

Review

• Treatment for mycosis fungoides partly

depends on the stage of cancer.

• You will likely receive multiple courses of first-

line treatments before moving on to second-

line treatments, if needed.

• Local skin treatments are often first used to

treat stage IA cancers. Second-line treatments

include systemic treatments and total skin

electron beam therapy.

• Generalized skin treatments are often first

used to treat stage IB and IIA cancers.

Second-line treatments include systemic

treatments and combination treatments.

• Local radiation therapy for skin tumors and

skin treatments for other lesions are first used

to treat limited stage IIB cancers. Second-

line treatments include total skin electron

beam therapy, systemic treatments, and

combination treatments.

• Total skin electron beam therapy, systemic

treatment with or without skin treatment, and

combination treatment are first used to treat

generalized stage IIB cancers. Second-line

treatments include multi-agent chemotherapy

and allogeneic stem cell transplant.

• Stage III first-line treatment depends on

whether there is blood involvement. If not,

skin treatments may be received. Systemic

treatment with or without skin treatment

is used if there is blood involvement.

Second-line treatments are combinations of

systemic treatments or systemic with skin

treatments. Third-line treatments include

systemic treatments, alemtuzumab, and

nonmyeloablative allogeneic transplant.

• Single-agent or multi-agent systemic

treatments are used to treat stage IV cancers.