NCCN Guidelines for Patients
Peripheral T-cell Lymphoma, Version 1.2016
Do I have PTCL?
CD19, CD20, CD30, CD45, TCRαß, TCRγ, and
kappa and lambda light chain proteins. Light chain
proteins are part of antibodies.
A translocation is a switching of parts between two
chromosomes. A gene rearrangement is the fusion
of one gene with another gene to create a new
gene. A translocation can be the cause of a gene
There are tests that detect translocations and gene
rearrangements. Such tests include karyotype and
ybridization). One or both
tests can aid in diagnosing certain subtypes of T-cell
Often, peripheral T-cell lymphomas have
rearrangements in the TCR (
Also, many anaplastic large cell lymphomas have
too many ALK-1 (
proteins. There are too many ALK proteins because
of a translocation between chromosomes 2 and 5—
referred to as t(2;5). In cases of anaplastic large cell
lymphoma, it is important to test for ALK1 status. This
can be done by IHC for ALK proteins or by genetic
irus) is important
for diagnosing a subtype of T-cell lymphoma. If you
have HTLV, the cancer may be adult T-cell leukemia
or lymphoma rather than peripheral T-cell lymphoma.
You will need to be tested if your doctor thinks HTLV
is important for understanding your diagnosis.
Testing of HTLV is done on a blood sample. Serology
is a test that looks for antibodies that target HTLV.
If the results from serology are unclear, PCR
eaction) can be done. PCR is a
process in which copies of a part of DNA are made,
which helps doctors find viruses.