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11

NCCN Guidelines for Patients

®

Peripheral T-cell Lymphoma, Version 1.2016

1

PTCL basics

Do I have PTCL?

CD19, CD20, CD30, CD45, TCRαß, TCRγ, and

kappa and lambda light chain proteins. Light chain

proteins are part of antibodies.

Genetic tests

A translocation is a switching of parts between two

chromosomes. A gene rearrangement is the fusion

of one gene with another gene to create a new

gene. A translocation can be the cause of a gene

arrangement.

There are tests that detect translocations and gene

rearrangements. Such tests include karyotype and

FISH (

f

luorescence

i

n

s

itu

h

ybridization). One or both

tests can aid in diagnosing certain subtypes of T-cell

lymphoma.

Often, peripheral T-cell lymphomas have

rearrangements in the TCR (

T

-

c

ell

r

eceptor) genes.

Also, many anaplastic large cell lymphomas have

too many ALK-1 (

a

naplastic

l

ymphoma

k

inase)

proteins. There are too many ALK proteins because

of a translocation between chromosomes 2 and 5—

referred to as t(2;5). In cases of anaplastic large cell

lymphoma, it is important to test for ALK1 status. This

can be done by IHC for ALK proteins or by genetic

tests.

HTLV tests

HTLV (

h

uman

T

-cell

l

ymphotropic

v

irus) is important

for diagnosing a subtype of T-cell lymphoma. If you

have HTLV, the cancer may be adult T-cell leukemia

or lymphoma rather than peripheral T-cell lymphoma.

You will need to be tested if your doctor thinks HTLV

is important for understanding your diagnosis.

Testing of HTLV is done on a blood sample. Serology

is a test that looks for antibodies that target HTLV.

If the results from serology are unclear, PCR

(

p

olymerase

c

hain

r

eaction) can be done. PCR is a

process in which copies of a part of DNA are made,

which helps doctors find viruses.