20

NCCN Guidelines for Patients

®

Peripheral T-cell Lymphoma, Version 1.2016

**2**

**Treatment planning**

**Prognostic scores**

**International Prognostic Index**

The IPI (

**I**

nternational

**P**

rognostic Index) is a scoring

system that uses risk factors to assess prognosis. A

risk factor is anything that increases your chances of

an event. The first IPI was created over 20 years ago.

In the standard version, 1 point is given for every risk

factor that describes you. The five risk factors are: 1)

older than 60 years of age; 2) lactate dehydrogenase

level above normal; 3) performance status score of

2 or greater; 4) stage III or IV; and 5) more than one

extranodal site. The total number of points is used to

assign you to one of four risk groups, which are:

•

**Low risk**

includes scores of 0 and 1.

•

**Low-intermediate risk**

includes a score of 2.

•

**High-intermediate risk**

includes a score of 3.

•

**High risk**

includes scores of 4 or more.

There is now more than one version of the IPI. There

is an age-adjusted version for people 60 years of age

and younger. One point is given for 1) stage III or IV;

2) lactate dehydrogenase level above normal; and 3)

performance status score of 2 or greater. A score of

0 is low risk, a score of 1 is low-intermediate risk, a

score of 2 is high-intermediate risk, and a score of 3

is high risk.

**Prognostic Index for PTCL-Unspecified**

The Prognostic Index for PTCL-Unspecified, or PIT,

is a newer version for peripheral T-cell lymphomas.

One point is given for 1) age greater than 60 years;

2) lactate dehydrogenase level above normal; 3)

performance status score of 2 or greater; and 4)

cancer in bone marrow. Two points are given for 1)

ages 61 to 74; and 2) lactate dehydrogenase level

greater than 3. Three points are given for age 75 and

older. The total number of points is used to assign

you to one of four risk groups, which are:

•

**Group 1**

includes a score of 0.

•

**Group 2**

includes a score of 1.

•

**Group 3**

includes a score of 2.

•

**Group 4**

includes scores of 3 and 4.