NCCN Guidelines for Patients
Peripheral T-cell Lymphoma, Version 1.2016
Overview of cancer treatments Radiation therapy
Radiation therapy consists of high-energy rays that
damage DNA. This either kills the cancer cells or
stops new cancer cells from being made. Radiation
can also harm normal cells. As a result, treatment
methods are always being improved to target the
tumor more precisely.
Involved-site radiation therapy
herapy) is sometimes
used to treat peripheral T-cell lymphoma. It can treat
lymph nodes in which the cancer first started and
cancer near to these nodes. It is given with a method
called EBRT (
method delivers radiation with a machine that is
outside your body.
Treatment planning with a simulation session is
needed. During simulation, pictures of the tumor will
be taken after your body is moved into the position
needed for treatment. CT with contrast is used. PET/
CT and MRI often enhance treatment planning. For
tumors near the breastbone, 4D-CT (
omography) or fluoroscopy can account
for tumor movement from breathing. If your breathing
causes large movements, motion control methods
during the scans may be used.
Using the scans, your treatment team will plan the
best radiation dose, number and shape of radiation
beams, and number of treatment sessions. Beams
are shaped with computer software and hardware
added to the radiation machine. Radiation beams are
aimed at the tumor with help from ink marks on your
During treatment, you will lie on a table in the same
position as done for simulation. Devices may be
used to keep you from moving. These may include a
mesh mask and body mold. You will be alone while
the therapists operate the machine from the nearby
The therapists will be able to see, hear, and speak
with you. As treatment is given, you may hear noises.
One session takes less than 10 minutes. The types of
• 3D-CRT (
herapy) – Treatment is completed
in about 6 weeks and uses photon beams that
match the shape of the tumor,
• IMRT (
– Treatment is completed in about 6 weeks
and uses photon beams of different strengths
based on the thickness of the tumor.
• Proton therapy – Treatment is completed in
about 6 weeks and uses proton beams that
deliver radiation mostly within the tumor.
herapy) can improve
how well the radiation beam targets some tumors.
IGRT uses the machine that delivers the radiation
to also take images of the tumor and normal body
structures. This can be done right before or during
treatment. These images are compared to the ones
taken during simulation. If needed, changes will be
made to your body position or the radiation beams.
Side effects of radiation
Most side effects of radiation depend on where the
treatment was given. However, many people feel
fatigue. Changes in skin are also common right after
treatment. Your treated skin may look and feel as if
it has a mild sunburn. It may also become dry, sore,
and feel painful when touched. You may also have
short-term hair loss, but only where treated.