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NCCN Guidelines for Patients


Peripheral T-cell Lymphoma, Version 1.2016



Genetic counseling | Treatment


Treatment guide

Peripheral T-cell lymphoma

Part 4 is a guide to the treatment

options for people with peripheral

T-cell lymphoma. Options are listed

by the subtype. This information is

taken from the treatment guidelines

written by NCCN experts of peripheral

T-cell lymphoma. These treatment

guidelines list options for people with

peripheral T-cell lymphoma in general.

Thus, your doctors may suggest

other treatment for you based on your

health and personal wishes. Fully

discuss your treatment options with

your doctor.

Treatment regimens

Combinations of drugs are almost always used to

treat newly diagnosed peripheral T-cell lymphoma.

First-line treatment is the first treatment given

after diagnosis. It is also called primary treatment.

Combinations of drugs are also often used if the

disease returns. Second-line treatment is given when

first-line treatment didn’t work or the cancer came


Throughout Part 4, the short names for the regimens

are listed. Below, the name of each drug for every

regimen is provided.

• CHOEP (cyclophosphamide, doxorubicin,

vincristine, etoposide, prednisone)

• CHOP (cyclophosphamide, doxorubicin,

vincristine, prednisone)

• CHOP/IVE/MTX (CHOP followed by

ifosfamide, etoposide, and epirubicin

alternating with intermediate-dose


• DHAP (dexamethasone, cisplatin, cytarabine)

• Dose-adjusted EPOCH (etoposide,

prednisone, vincristine, cyclophosphamide,


• ESHAP (etoposide, methylprednisolone,

cytarabine, cisplatin)

• GDP [gemcitabine, dexamethasone, (cisplatin

or carboplatin)]

• GemOx (gemcitabine, oxaliplatin)

• GVD (gemcitabine, vinorelbine, liposomal


• HyperCVAD/R-MTX-Ara-C

(cyclophosphamide, vincristine, doxorubicin,

and dexamethasone alternating with high-

dose methotrexate and cytarabine)

• ICE (ifosfamide, carboplatin, etoposide)

During and after cancer treatment, you may be

treated to prevent or control other health conditions.

Such actions are a part of supportive care. Health

conditions that are a concern for some people include

tumor lysis syndrome, reactivated viruses, and other

infections. Talk to your doctor about which health

conditions you may develop as a result of cancer