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NCCN Guidelines for Patients


Peripheral T-cell Lymphoma, Version 1.2016



Genetic counseling | Treatment


Treatment guide

Peripheral T-cell lymphoma, NOS

Chart 4.1.1

lists first-line treatment options for

peripheral T-cell lymphoma, NOS. Joining a clinical

trial that is right for your disease is the preferred

option of the NCCN experts. If a clinical trial isn’t

an option, a second option is 6 cycles of a standard

chemotherapy regimen. Regimens are listed in the

chart. You may also receive involved-site radiation

therapy to lower your chances of the cancer returning.

After chemotherapy, the results need to be assessed

with testing. Any imaging test that showed cancer

before treatment should be repeated. If PET/CT still

shows signs of cancer, a biopsy may be needed to

confirm before receiving more treatment.

There are three options if testing finds no signs of

cancer. The first option is to join a clinical trial of

additional drug treatment or of a stem cell transplant.

You must be fairly healthy to undergo a transplant.

The second option is to receive an autologous stem

cell transplant outside of a clinical trial. Before or after

the high-dose chemotherapy portion of the transplant,

you may receive radiation therapy. A transplant is

an option because there is some proof that it may

improve results, but more research is still needed.

The third option is observation. Observation or

“watch-and-wait” is a period of testing to assess for

changes in cancer status. If signs of cancer appear

during observation, see Chart 4.1.2 for treatment

options that don’t include a transplant or Chart 4.1.3

for treatment options that do include a transplant.

If testing finds cancer after 6 cycles of chemotherapy,

you have treatment options. Your options partly

depend on whether you can and want to undergo a

stem cell transplant. If a stem cell transplant will not

be part of your treatment, see Chart 4.1.2. Treatment

options in Chart 4.1.3 are for people who plan to have

a transplant.

Chart 4.1.2

lists second-line options that don’t

include a stem cell transplant. Second-line treatment

is received when first-line treatment didn’t work or

the cancer came back. Options include joining a

clinical trial, drug treatment, and radiation therapy

as supportive care. Supportive care aims to reduce

symptoms of cancer.