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44

NCCN Guidelines for Patients

®

Peripheral T-cell Lymphoma, Version 1.2016

3

DCIS

Genetic counseling | Treatment

4.2 Anaplastic large cell lymphoma

4

Treatment guide

Anaplastic large cell ly phoma

Chart 4.2.1 First-line treatment

Cancer stage

Treatment options

Stage I and II

• 6 cycles of CHOP-21 or CHOEP ± involved-site radiation therapy

• 3 or 4 cycles of CHOP-21 or CHOEP + involved-site radiation therapy

Stage III and IV

• 6 cycles of CHOP-21 or CHOEP

Chart 4.2.2 Second-line treatment without stem cell transplant

Treatment options

• Clinical trial

• Drug treatment

Preferred treatments

◦◦ Belinostat

◦◦ Brentuximab vedotin

◦◦ Pralatrexate

◦◦ Romidepsin

Other treatments

◦◦ Alemtuzumab

◦◦ Bendamustine

◦◦ Bortezomib

◦◦ Gemcitabine

• Supportive care, radiation therapy

ALK Positive