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45

NCCN Guidelines for Patients

®

Peripheral T-cell Lymphoma, Version 1.2016

3

DCIS

Genetic counseling | Treatment

In Part 4.2, treatment options are divided into two

sections: ALK positive and ALK negative. The first

section is for people who have anaplastic large

cell lymphoma that has ALK proteins. The second

section is for people who have anaplastic large cell

lymphoma without ALK proteins.

Chart 4.2.1

lists first-line treatment options for

anaplastic large cell lymphomas with ALK proteins.

CHOP and CHOP-like regimens have had good

results among this subtype. Two options are listed for

stage I and II cancers. Most commonly, 6 cycles of

chemotherapy with or without involved-site radiation

therapy are given. However, at times, fewer cycles

followed by radiation therapy may be advised. Stage

III and IV cancers are treated only with chemotherapy

since the cancer is too widespread for radiation

therapy.

After treatment, the results will be assessed with

testing. If first-line treatment didn’t work or the cancer

returns, you have options. Your options partly depend

on whether you can and want to undergo a stem cell

transplant. If a stem cell transplant will not be part of

your treatment, see Chart 4.2.2. Treatment options

in Chart 4.2.3 are for people who plan to have a

transplant.

Chart 4.2.2

lists second-line options that don’t

include a stem cell transplant. Second-line treatment

is received when first-line treatment didn’t work or

the cancer came back. Options include joining a

clinical trial, drug treatment, and radiation therapy

as supportive care. Supportive care aims to reduce

symptoms of cancer.

4

Treatment guide

Anaplastic large cell ly phoma