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ALK Negative

Chart 4.2.4 First-line treatment

Treatment options

Test results

Treatment options

No signs

of cancer

Cancer looks

smaller, the

same, or larger

Preferred treatments

◦◦ CHOEP

◦◦ CHOP-14

◦◦ CHOP-21

◦◦ Dose-adjusted EPOCH

Other treatments

◦◦ HyperCVAD/R-MTX-Ara-C

• Observation

• Clinical trial

• Clinical trial (preferred)

• 6 cycles of chemotherapy ±

involved-site radiation therapy

• Treatment with stem cell transplant

• Treatment without stem cell transplant

• Consider autologous stem cell

transplant ± radiation therapy

Chart 4.2.5 Second-line treatment without stem cell transplant

Treatment options

• Clinical trial

• Drug treatment

Preferred treatments

◦◦ Belinostat

◦◦ Brentuximab vedotin

◦◦ Pralatrexate

◦◦ Romidepsin

Other treatments

◦◦ Alemtuzumab

◦◦ Bendamustine

◦◦ Bortezomib

◦◦ Gemcitabine

• Supportive care, radiation therapy

48

NCCN Guidelines for Patients

®

Peripheral T-cell Lymphoma, Version 1.2016

4

Treatment guide

Anaplastic large cell lymphoma