NCCN Guidelines for Patients
Ovarian Cancer, Version 1.2017
Leuprolide acetate – This drug causes
the ovaries to make less estrogen and
progesterone. It is in a class of drugs called
Megestrol acetate – This drug stops the effect
of estrogen on cancer cell growth. It is in a
class of drugs called progestins.
Hormone therapy can cause a number of side
effects. A side effect is an unhealthy or unpleasant
response to treatment. The side effects may be mild
or severe. Symptoms of menopause are common.
Such symptoms include hot flashes, changes in
mood, vaginal dryness, trouble sleeping, and night
sweats. Other common side effects of hormone
therapy are vaginal discharge, weight gain, swelling
in the hands and feet, fatigue, and less interest in
sex. Blood clots are a rare but serious side effect of
tamoxifen. Aromatase inhibitors can weaken your
bones and may also cause joint and muscle pain.
All of the side effects of hormone therapy are
not listed here. Ask your treatment team for a full
list of common and rare side effects of the drug
you receive. If a side effect bothers you, tell your
treatment team. There may be ways to help you feel
A clinical trial is a type of research study that people
choose to take part in as part of their cancer care.
Clinical trials help doctors learn how to prevent,
diagnose, and treat a disease like cancer. Because
of clinical trials, doctors find safe and helpful ways to
improve cancer care. This guide provides information
about many of those tests and treatments used to
help people with cancer.
edicine) is a group of treatments
sometimes used by people with cancer.
Many CAMs are being studied to see if they
are truly helpful.
Complementary medicines are meant to
be used alongside standard therapies,
most often for relaxation, improving
your health, or to prevent or reduce side
Alternative medicine is treatment
or techniques that are used instead
of standard treatments such as
chemotherapy or radiation. Some are
sold as cures even though they haven’t
been proven to work in clinical trials.
Many cancer centers or local hospitals
have complementary therapy programs that
offer acupuncture, yoga, and other types of
It’s important to tell your treatment team if
you are using any complementary medicine,
especially supplements, vitamins, or herbs.
Some of these things can interfere with your
cancer treatment. For more information
about CAM, ask your doctor and visit the
websites in Part 7.