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69

NCCN Guidelines for Patients

®

:

Ovarian Cancer, Version 1.2017

6

Treatment guide

Low-grade serous/endometrioid epithelial

Guide 16. Low-grade (grade 1) serous/endometrioid epithelial carcinoma

Stage Adjuvant treatment options

Stage IA-IB

ª

• Observe

Stage IC-II

ª

• Observe

or

• IV taxane/carboplatin for 3 to 6 cycles

or

• Hormone therapy

Stage III-IV

ª

• Chemotherapy

or

• Hormone therapy

Borderline

ª

• See Guides 17 and 18

Guide 16

covers adjuvant treatment options for

stage I to IV, and borderline disease. For stages I

and II, observation may be option. Chemotherapy is

a treatment option for stage IC to IV, but low-grade

serous/endometrioid epithelial carcinoma may not

respond as well to this treatment. Stage IC to II

chemotherapy may include IV carboplatin with either

paclitaxel or docetaxel. Another recommended

treatment is hormone therapy, which includes

anastrozole, letrozole, leuprolide, or tamoxifen. Stage

III to IV treatment options include chemotherapy

(same given for epithelial ovarian cancer) or

hormone therapy.

For those with borderline low-grade serous/

endometrioid epithelial carcinoma, fertility-sparing

surgery is an option. Adjuvant treatment options for

borderline disease are listed in Guides 17 and 18.

The options include observation, chemotherapy, or

hormone therapy.