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74

NCCN Guidelines for Patients

®

:

Ovarian Cancer, Version 1.2017

6

Treatment guide

Malignant sex cord-stromal tumors

Malignant sex cord-stromal tumors

Guide 21. Malignant sex cord-stromal tumors

Staging Adjuvant treatment options

Stage IA to IC

• Fertility sparing

surgery with

complete staging

ª

ª

ª

• Stage I low risk

• Observe

• Stage I high risk

or

• Intermediate risk

• Observe

or

• Consider platinum-based chemotherapy

All others

• Complete staging

• Stage II-IV

• Platinum-based chemotherapy

or

• Radiation for limited disease

Malignant sex cord-stromal tumors include

granulosa cell tumors and Sertoli-Leydig cell tumors.

Granulosa cell tumors are the more common of the

two. Malignant sex cord-stromal tumors are rare.

Malignant sex cord-stromal tumors are usually a

slow-growing (indolent) type of ovarian cancer. It is

often found at an early stage of disease.

Guide 21

starts with staging of sex cord-stromal

tumors. If you want to have babies after treatment,

fertility-sparing surgery is offered with complete

staging. Once the stage is known, patients with stage

I disease are referred to as low risk or high risk.

Those with low risk may be observed. Those with

stage I high risk or intermediate (middle) risk may

be observed or get a platinum-based chemotherapy.

For stage II to IV, platinum-based chemotherapy or

radiation to a limited area is recommended.

Chemotherapy drugs given to treat malignant sex

cord-stromal tumors include BEP (

b

leomycin,

e

toposide, and

c

isplatin), as well as paclitaxel

and cisplatin or carboplatin. If you are prescribed

bleomycin, pulmonary function tests may be before

treatment. The pulmonary function tests will check to

see if your lungs are working properly.