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54

NCCN Guidelines for Patients

®

:

Pancreatic Cancer, Version 1.2017

Guide 15. Second-line treatment

Performance

status rating First-line treatment Second-line treatment

Good

performance

status

ª

• Had

gemcitabine-

based

chemotherapy

ª

• Clinical trial

(preferred)

or

• Fluoropyrimidine

based-chemotherapy

or

• Chemoradiation (if

not given before)

and if only site of

progression is primary

site

ª

• If poor

performance

status,

palliative and

best supportive

care are

offered

ª

• Had

fluoropyrimidine-

based

chemotherapy

ª

• Clinical trial

(preferred)

or

• Gemcitabine-based

chemotherapy

or

• 5-FU with leucovorin,

and liposomal

irinotecan (if not given

irinotecan before)

or

• Chemoradiation (if

not given before)

and if only site of

progression is primary

site

ª

• If good

performance

status and

disease

progression, a

clinical trial is

recommended

5

Treatment guide Locally advanced unresectable pancreatic cancer