NCCN Guidelines for Patients
Prostate Cancer, Version 1.2016
diarrhea, and low counts of neutrophils (neutropenia)
with or without fever. Neutrophils are a type of white
Docetaxel is also used to treat metastases after
ADT fails to stop cancer growth. Three-week cycles
are also advised. The number of cycles you receive
should be based on how much the drug is helping
and the severity of side effects.
Cabazitaxel is an option if docetaxel fails to work.
However, the benefits of cabazitaxel are small and
the side effects can be severe. You should not take
cabazitaxel if your liver, kidney, or bone marrow is not
working well or if you have severe neuropathy.
You may have a severe allergic reaction within a
few minutes of receiving cabazitaxel. Common side
effects are fatigue, neuropathy, hematuria, back pain,
bruising, shortness of breath, cough, joint pain, and
hair loss. Severe stomach and intestinal problems,
illness from too few white blood cells, and kidney
failure may occur.
Not all of the side effects of chemotherapy are listed
here. Please ask your treatment team for a complete
list of common and rare side effects. If a side effect
bothers you, tell your treatment team. There may be
ways to help you feel better.
Radiopharmaceuticals are drugs that contain
a radioactive substance. Radium-223 is a
radiopharmaceutical that is injected into the body to
treat prostate cancer that has spread to the bone. It
may improve survival time. It may also delay bone
problems and the need for radiation to treat pain.
Since the chemical makeup of radium-223 is similar
to calcium, it travels to bone damaged by cancer.
Once it reaches the bone, it delivers radiation that
kills the nearby cancer cells. The radiation doesn’t
travel far so healthy tissue is spared.
Radium-223 may lower blood cells counts. Thus, you
may get infections and bruises and have unusual
bleeding or fatigue. Since radium-223 leaves the
body through the gut, other common side effects are
nausea, diarrhea, and vomiting.
89Sr (strontium-89) and 153Sm (Samarium-153) also
are radiopharmaceuticals. They haven’t been shown
to extend life. However, they may relieve pain caused
by cancer metastases in the bone. They also may
cause a decrease in the number of blood cells.
Overview of cancer treatments Radiopharmaceuticals