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46

NCCN Guidelines for Patients

®

Prostate Cancer, Version 1.2016

5

Treatment Guide: Initial treatment

48

Very low risk

This section lists treatment options for men who meet five conditions: 1) cancer stage

T1c, N0, M0; 2) PSA level less than 10 ng/mL; 3) PSA density less than 0.15 ng/mL/g; 4)

Gleason score 6 or less; and 5) cancer in fewer than three biopsy cores and in half or less

of any core.

50

Low risk

This section lists treatment options for men who meet three conditions: 1) cancer stage

T1a, T1b, T1c, or T2a and N0, M0; 2) PSA level less than 10 ng/mL; and 3) Gleason score

6 or less.

54

Intermediate risk

This section lists treatment options for men who meet one of three conditions: 1) cancer

stage T2b or T2c and N0, M0, 2) PSA level between 10 and 20 ng/mL, or

3) Gleason score 7. If you meet more than one condition, your doctor may treat the cancer

as high risk.

58

High risk

This section lists treatment options for men who meet one of three conditions: 1) cancer

stage T3a, N0, M0; 2) PSA level greater than 20 ng/mL; or 3) Gleason score between 8

and 10. If you meet more than one condition, your doctor may treat the cancer as very

high risk.

60

Very high risk

This section lists treatment options for men who meet one of three conditions: 1) cancer

stage T3b or T4 and N0, M0; 2) primary Gleason grade 5; or 3) more than 4 biopsy cores

with Gleason scores between 8 and 10.

62

Regional cancer

This section lists treatment options for cancer staged as Any T, N1, M0.

62

Metastatic cancer

This section lists treatment options for cancer staged as M1.

64

Review