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NCCN QUICK GUIDE

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Acute Lymphoblastic Leukemia, Version 1.2017

PAT-N-1001-0717

NCCN.org - for Clinicians

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NCCN.org/patients - for Patients

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What are the postremission consolidation and

maintenance options?

Blinatumomab (persistent or late MRD) or consider allogeneic stem cell transplant for

consolidation (for AYAs and healthy older adults)

Then, start follow-up testing

Continue multiagent chemotherapy regimen for consolidation

Then, maintenance with vincristine and prednisone, methotrexate, and 6-MP

56 AYAS 60 Older Adults

How will I know if treatment works?

Doctors give follow-up tests during and after treatment to check how well treatment

worked.

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An outcome or improvement caused by treatment is called a treatment response.

A complete remission is when no leukemia cells are found in blood or bone marrow

when viewed with a microscope and all signs and symptoms of ALL are gone.

If induction doesn't put ALL into complete remission, it is called refractory ALL.

A relapse is when ALL comes back after a complete remission.

At the end of treatment, you will have scheduled follow-up tests for at least 3 years.

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What are the next options if prior treatment fails (refractory)

or ALL comes back (relapsed)?

Clinical trial

Chemotherapy regimen for relapsed or refractory ALL ± allogeneic SCT

Blinatumomab

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How do you decide between options?

Ask your doctors many questions. Also, you could get a second opinion, attend support

groups, and compare the benefits and risks of different options.

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NCCN Guidelines

for Patients

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