NCCN Quick Guide™ | Acute Lymphoblastic Leukemia - Treatment Planning
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NCCN QUICK GUIDE

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Acute Lymphoblastic Leukemia, Version 1.2017

PAT-N-1001-0717

NCCN.org - for Clinicians

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NCCN.org/patients - for Patients

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How do doctors group ALL for treatment planning?

Cell subtypes

Doctors classify ALL into two broad groups based on the type of

lymphocyte in which it started.

These groups are called cell subtypes.

The two main cell subtypes are B-cell ALL and T-cell ALL.

B-cell ALL starts in young B-lymphocytes

T-cell ALL starts in young T-lymphocytes

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Cytogenetic

subtypes

Doctors also classify ALL based on the types of abnormal

chromosome changes found in the leukemia cells.

These groups are called cytogenetic subtypes.

The two main cytogenetic subtypes are based on whether or not the

leukemia cells have the abnormal Philadelphia chromosome.

Ph-negative ALL: The leukemia cells do not have the Philadelphia

chromosome

Ph-positive ALL: The leukemia cells have the Philadelphia

chromosome

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Patient age

groups

Your age and health status are key factors doctors use to decide if

you should receive very intensive treatments.

Thus, doctors divide patients into two groups based on age.

AYAs (

a

dolescents and

y

oung

a

dults): Patients who are 15 to 39

years of age

Older adults: Patients who are 40 years of age or older

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What is treatment like?

It depends on which treatment you have. There is more than one treatment to choose from.

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All treatments can cause side effects. But, how your body will react can’t be fully known.

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Share your thoughts, goals, and concerns about treatment with your doctors.

This can help you get the best treatment plan for you.

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NCCN Guidelines

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