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NCCN QUICK GUIDE

tm

Acute Lymphoblastic Leukemia, Version 1.2017

This NCCNQUICK GUIDE

tm

sheet summarizes key points from the complete

NCCN Guidelines for Patients ® : Acute Lymphoblastic Leukemia . T

hese guidelines explain which tests and treatments are

recommended by experts in cancer. To view and download the guidelines, visit

NCC N.or g/patients

or, to order printed copies, visit Amazon.com

What is Ph-positive ALL?

Ph-positive ALL means the leukemia cells have the abnormal Philadelphia chromosome.

The Ph chromosome contains the abnormal

BCR-ABL

gene.

Among adults with ALL, about 25 out of 100 have Ph-positive ALL. It is more rare in

children.

28

How do doctors choose treatment options?

Treatment options differ based on the presence of the Ph chromosome and your age.

28

Doctors divide patients into two main groups based on age:

AYAs (

a

dolescents and

y

oung

a

dults) – patients who are 15 to 39 years of age

Older adults – patients who are 40 years of age or older

28

Treatment for ALL is very complex and intensive. It is given in three main steps, called

phases:

Remission induction aims to kill all the leukemia cells and put ALL into remission.

Postremission consolidation aims to kill any leukemia cells left after ALL is in remission.

Maintenance aims to keep up (maintain) good results of induction and consolidation.

35

CNS (

c

entral

n

ervous

s

ystem) preventive treatment is given during all phases to kill

leukemia cells that may spread to fluid around the brain and spinal cord.

35

What are the remission induction options?

AYAs

Clinical trial

Multiagent chemotherapy regimen + TKI (

t

yrosine

k

inase

i

nhibitor)

TKI + corticosteriods

If complete remission after any option above, test for MRD (

m

inimal

r

esidual

d

isease)

46

Older adults

Clinical trial

Multiagent chemotherapy regimen + TKI (if <65 years old or in good

health)

TKI + corticosteroids (if ≥65 years old or in poor health)

TKI + chemotherapy (if ≥65 years old or in poor health)

If complete remission after any option above, test for MRD

50

NCCN Guidelines

for Patients

®

Page Number

Ü

Version 1.2017

NCCN

GUIDELINES

FOR PATIENTS

®

NCCN QUICK GUIDE

tm

Acute Lymphoblastic

Leukemia

Treatment for Ph-positive

ALL