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NCCN QUICK GUIDE

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Acute Lymphoblastic Leukemia, Version 1.2017

PAT-N-1001-0717

NCCN.org - for Clinicians

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NCCN.org/patients - for Patients

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What are the postremission consolidation and

maintenance options?

Options for AYAs and older adults who are <65 years old or in good health:

Consolidation with an allogeneic stem cell transplant if a well-matched donor is available

Then, consider maintenance with a TKI

If a donor is not available, continue multiagent chemotherapy regimen + TKI for

consolidation

Then, TKI and maintenance with vincristine and prednisone, methotrexate, and 6-MP

48 AYAS 52 Older Adults

For older adults who are ≥65 years old or in poor health:

Continue TKI ± corticosteroids or TKI ± chemotherapy for consolidation

Then,TKI and maintenance with vincristine and prednisone, methotrexate, and 6-MP

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How will I know if treatment works?

Doctors give follow-up tests during and after treatment to check how well treatment

worked.

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An outcome or improvement caused by treatment is called a treatment response.

A complete remission is when no leukemia cells are found in blood or bone marrow whe

n

viewed with a microscope and all signs and symptoms of ALL are gone.

If induction doesn't put ALL into complete remission, it is called refractory ALL.

A relapse is when ALL comes back after a complete remission.

At the end of treatment, you will have scheduled follow-up tests for at least 3 years.

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Next options if prior treatment failed or ALL comes back

Clinical trial

TKI ± chemotherapy

TKI ± corticosteroids

Blinatumomab (If no response to 2 TKIs)

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How do you decide between options?

Ask your doctors many questions. Also, you could get a second opinion, attend support

groups, and compare the benefits and risks of different options.

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NCCN Guidelines

for Patients

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