NCCN Quick Guide™ | Chronic Myeloid Leukemia

1 of 2 2018 NCCN QUICK GUIDE tm Chronic Myeloid Leukemia, 2018 This NCCNQUICK GUIDE tm sheet summarizes key points from the complet e NCCN Guidelines for Patients ® : Chronic Myeloid Leukemia . T hese guidelines explain which tests and treatments are recommended by experts in cancer. To view and download the guidelines, visit NCC N.or g/ patients or, to order printed copies, visit What is CML (chronic myeloid leukemia)? CML is a rare blood cancer. It is a cancer of stem cells that make granulocytes. Granulocytes are a type of white blood cell. 10 There are 3 phases of CML. The chronic phase is the first phase. The accelerated phase is the second phase. The third and final phase is called the blast phase. 11 What tests are needed to confirm CML and plan treatment? „„ A report of your health history and an exam of your body. 14 „„ Tests of blood cell counts and chemicals. 15 „„ Tests of your bone and bone marrow. 16 „„ Tests for CML markers—Philadelphia chromosome and BCR-ABL1 gene. 17 „„ Test for hepatitis B. 18 What are the treatment options for chronic CML? „„ The first treatment received is a: TKI ( t yrosine k inase i nhibitor): 1) imatinib or 2) dasatinib or nilotinib, or Clinical trial. 28 „„ Results of treatment will be carefully tracked. Your doctor will look for a drop in the number of CML cells. 29 „„ If treatment does not work well, you will receive more tests to learn why. 30 „„ At some point, you may need to switch to a new TKI, increase imatinib dose, or talk to your doctor about a HCT ( h ematopoietic c ell t ransplant). 31 NCCN Guidelines for Patients ® Page Number Ü NCCN GUIDELINES FOR PATIENTS ® NCCN QUICK GUIDE tm Chronic Myeloid Leukemia