NCCN Quick Guide™ | Nodular lymphocyte-predominant

1 of 2 NCCN QUICK GUIDE tm Non-Hodgkin Lymphoma – NLPHL, 2019 This NCCNQUICK GUIDE tm sheet summarizes key points from the complete NCCN Guidelines for Patients ® : Hodgkin Lymphoma. These guidelines explain which tests and treatments are recommended by experts in cancer. To view and download the guidelines, visit or, to order printed copies, visit What is Hodgkin lymphoma? h There are 2 types of Hodgkin lymphoma: classic Hodgkin lymphoma (CHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). NLPHL is the focus of this Quick Guide™. h NLPHL is a very rare type of Hodgkin lymphoma. It develops and responds to treatment differently than CHL. Over time, NLPHL can transform into an aggressive type of non-Hodgkin lymphoma called diffuse large B-cell lymphoma (DLBCL). 10 What health care is given before treatment? Biopsy and testing Excisional lymph node biopsy and testing of the removed lymph node(s) using immunohistochemistry (IHC). 14 Medical history and physical exam h Check for “B symptoms” (unexplained fever, night sweats, extreme weight loss without dieting) and other symptoms (alcohol intolerance, severe itching, fatigue) h Examination of neck, armpits, groin, spleen, and liver 15 Blood tests h Complete blood count (CBC), erythrocyte sedimentation rate (ESR), comprehensive metabolic panel, and measurement of serum lactate dehydrogenase 17 Imaging tests Positron emission tomography (PET) and computed tomography (CT) with contrast 18 Other testing and care as needed h Pregnancy testing h Fertility preservation h Bone marrow biopsy h Other imaging tests h Heart and lung function tests h Vaccines h Testing for HIV, hepatitis B and C h Help to quit smoking 20 NCCN Guidelines for Patients ® Page Number Ü NCCN QUICK GUIDE tm Hodgkin lymphoma Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) 2019