NCCN Quick Guide™ | Multiple Myeloma

2 of 2 NCCN QUICK GUIDE tm Multiple Myeloma, 2018 PAT-N-1023-1017 What are the options after primary treatment for active myeloma? Myeloma responded to primary treatment „„ Autologous stem cell transplant ( high-dose chemotherapy to destroy cells in the bone marrow and then replace them with your own healthy blood stem cells) „„ Allogeneic stem cell transplant (high-dose chemotherapy to destroy cells in the bone marrow and then replace them with blood stem cells from another person called a donor) „„ Stay on primary treatment (until best response) or maintenance therapy. If relapse or progression, see options below. 47 Myeloma did not respond to primary treatment „„ Therapy for previously treated myeloma therapy (see page 49) „„ Clinical trial „„ Autologous stem cell transplant „„ Allogeneic stem cell transplant * All options may be followed with palliative care What are the options after a stem cell transplant? You had an allogeneic stem cell transplant If tests show a treatment response or stable disease: „„ Maintenance therapy on a clinical trial „„ Observation If tests show progressive disease: „„ Therapy for previously treated myeloma on or off a clinical trial „„ Donor lymphocyte infusion 51 You had an autologous stem cell transplant If tests show a treatment response or stable disease: „„ Maintenance therapy „„ Clinical trial If progressive disease after any option above: „„ Therapy for previously treated myeloma, or clinical trial ± additional autologous stem cell transplant, or allogeneic stem cell transplant If tests show progressive disease: „„ Therapy for previously treated myeloma „„ Clinical trial „„ Allogeneic stem cell transplant 52 NCCN Guidelines for Patients ® Page Number Ü NCCN.org - for Clinicians | NCCN.org/patients - for Patients DONATENOW nccnfoundation.org The NCCN QUICK GUIDE tm series and NCCN Guidelines for Patients ® are supported by charitable donations made to the NCCN Foundation ® . For more details and the full library of patient and caregiver resources, visit NCCN.org/patients.

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