2 of 2 NCCN QUICK GUIDE tm Mantle Cell Lymphoma, 2017 PAT-N-1014-0917 Is treatment needed now? There are rare times when mantle cell lymphoma does not need to be treated right away. A “watch-and-wait” approach may be an option if the cancer is not causing symptoms or is slow growing. 37 What are the treatment options? Stage I and limited stage II First-line treatment Immunochemotherapy ± radiation therapy Radiation therapy 38 Second-line treatment (depends on prior treatment) Chemotherapy ± rituximab Immunomodulator Clinical trial Radiation therapy 40 Extensive stage II and stages III and IV First-line treatment Immunochemotherapy ± blood stem cell transplant 42 Second-line treatment Clinical trial Radiation therapy Chemotherapy ± rituximab Targeted therapy Ibrutinib, lenalidomide, and rituximab Lenalidomide ± rituximab 44 What are some tips for making good treatment decisions? Ask your doctors many questions. Also, you could get a second opinion, attend support groups, and compare pros and cons. 47 NCCN Guidelines for Patients ® Page Number Ü NCCN.org - for Clinicians | NCCN.org/patients - for Patients DONATENOW nccnfoundation.org The NCCN QUICK GUIDE tm series and NCCN Guidelines for Patients ® are supported by charitable donations made to the NCCN Foundation ® . For more details and the full library of patient and caregiver resources, visit NCCN.org/patients.