NCCN Quick Guide™ | Waldenstrom's Macroglobulinemia / Lymphoplasmacytic Lymphoma
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NCCN QUICK GUIDE

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Waldenström’s Macroglobulinemia, Version 1.2017

PAT-N-0963-0117

What are my options?

Observation

Your doctor will watch you closely to see if the cancer is

growing. You will both decide when and if you should start

treatment.

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Plasmapheresis

Plasmapheresis is a process that removes IgM from the

blood.

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Chemotherapy

Chemotherapy, or chemo, is a main systemic cancer treatment.

Systemic treatment travels throughout the body.

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Steroids

Steroids are a type of drug that is often used to relieve

inflammation. Steroids also are toxic to lymphoma cells and

therefore have strong anti-cancer effects.

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Targeted therapy

Targeted therapies are drugs that sometimes can directly kill

cancer cells. They can be used alone or combined with other

drugs.

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Immunomodulators

Immunomodulators are drugs that modify different parts of your

immune system. The exact function of these drugs is not known.

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Stem cell transplant

A stem cell transplant replaces damaged or destroyed stem cells

with healthy stem cells, which form new marrow and blood cells.

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Clinical trials

A clinical trial is a type of research study that people chose to

take part in.

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When is treatment given?

Primary treatment

The first treatment options for WM are called primary treatment.

You should get this treatment if you have symptoms of WM.

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Relapsed or

refractory treatment

Treatment for WM that didn’t respond to (refractory) or reappears

(relapsed) after the first treatment.

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How do I decide between my options?

Ask your doctors many questions. Also, you could get a second opinion, attend support

groups, and compare the benefits and risks.

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