4.3 Treatment after progression
Some GISTs grow while taking drug treatment.
Doctors call this cancer progression. Treatment
options after progression are presented next.
lists treatment options based on
whether there is limited or widespread growth.
If limited growth, you may keep taking imatinib
and consider local treatments. Otherwise, you may
increase the dose of imatinib or start taking sunitinib.
NCCN Guidelines for Patients
Soft Tissue Sarcoma, Version 1.2014
Gastrointestinal stromal tumors Treatment after progression
Chart 4.3.1 First progression
Chart 4.3.2 Second progression
• Clinical trial
• Alternate treatments (little research done)
• Supportive care
Increase dose of imatinib
Change to sunitinib
Continue imatinib and consider:
• Surgery if possible
• Ablation, embolization, or chemoembolization
• Palliative radiation therapy if cancer spread to
Increase dose of imatinib or change to sunitinib