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NCCN Guidelines for Patients


Breast Cancer - Carcinoma in Situ

(stage 0)

, Version 1.2016



Risk-reduction treatment

Pathology review

All biopsy samples must be viewed by a pathologist.

The type and extent of the disease will be confirmed.

Among women with LCIS, over half have LCIS in

more than one lobule. Sometimes, both LCIS and

breast cancer are found. The breast cancer may be

confined to or have spread beyond the breast ducts.

If an invasive breast cancer is found, read the NCCN

patient book related to the cancer stage.

The pathology results will be recorded in a report. It’s

a good idea to get a copy of your pathology report. It’s

used to plan treatment.

Risk-reduction treatment

Although LCIS increases your risk for breast cancer,

you may not need risk-reduction treatment. There

are many other risk factors to consider. One very

important risk factor is if any of your blood relatives

have had breast or ovarian cancer, especially at a

young age.

Using your medical and family history, your doctor

will tell you, in general, how likely you are to get

breast cancer. If there’s a history of cancer in your

family, you should be referred for genetic counseling.

A genetic counselor is an expert in gene mutations

related to cancer. The counselor can better determine

your risk for breast cancer.

The counselor may suggest testing for mutations in

genes that are related to breast cancer and passed

down in families. Such mutations can occur in




genes. Normal


genes help to

prevent tumor growth. Women with




gene mutations are more likely to have breast

and ovarian cancer than other women.

Based on all risk factors, your genetic counselor will

advise if risk-reduction treatment would be helpful.

However, it’s your choice whether to start treatment.

Risk-reduction treatment is briefly described next.

Lifestyle changes

Changes in your lifestyle may reduce your chances of

developing breast cancer. Examples are eating more

healthfully, limiting alcohol use, exercising more, and

achieving a healthy body weight. Your doctor can

suggest lifestyle changes that are specific to you.

Endocrine therapy

Female hormones help some breast cancers grow.

Endocrine therapy includes treatments that stop

cancer growth caused by hormones. Endocrine

therapy is sometimes called hormone therapy and