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44

NCCN Guidelines for Patients

®

Breast Cancer - Early-Stage

(STAGES I AND II)

, Version 1.2016

4

Chemotherapy and HER2 inhibitors Treatment options: HER-2 negative cancer

Treatment options: HER-2 negative cancer

Chart 4.1 Hormone receptor-negative (triple-negative breast cancer)

Size of breast tumor

Size of lymph node tumors

Do I need chemotherapy?

0.5 cm or smaller

No tumors

Unlikely

Tiny (≤2.0 mm) tumors

Consider chemotherapy

0.51 to 1.0 cm

None or tiny (≤2.0 mm) tumors

Consider chemotherapy

Larger than 1.0 cm Any size

Yes

Chart 4.2 Hormone receptor-positive

Size of breast tumor Size of lymph node tumors RT-PCR score Do I need chemotherapy?

0.5 cm or smaller

No tumors

Unlikely

Tiny (≤2.0 mm) tumors

Consider chemotherapy

0.51 or larger

None or tiny (≤2.0 mm)

tumors

Not done

Consider chemotherapy

<18

Unlikely

18–30

Consider chemotherapy

≥31

Yes

Any size

Larger than 2.0 mm

Yes