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NCCN Guidelines for Patients


Breast Cancer - Early-Stage


, Version 1.2016


Endocrine therapy



• Endocrine therapy is given after surgery to

lower the chances of breast cancer returning.

• Endocrine therapy is used to treat only

hormone receptor–positive breast cancer.

• For rare cancers that aren’t likely to spread

outside the breast, endocrine therapy is

advised if the breast tumor is larger than 3 cm

or the lymph node tumor is larger than 2 mm.

• For breast cancers that have a higher chance

of spreading, endocrine therapy is advised

unless there is no cancer in lymph nodes.

• There are 4 main types of endocrine therapy.

Antiestrogens block the action of estrogen.

Aromatase inhibitors, ovarian ablation, and

ovarian suppression lower the amount of

hormones in the body.

• Which regimens for endocrine therapy are

advised is based on menopausal status.

Medicines used for endocrine therapy are

taken for 5 to 10 years.

• Endocrine therapy causes symptoms of