NCCN Guidelines for Patients
Breast Cancer - Early-Stage
(STAGES I AND II)
, Version 1.2016
• Endocrine therapy is given after surgery to
lower the chances of breast cancer returning.
• Endocrine therapy is used to treat only
hormone receptor–positive breast cancer.
• For rare cancers that aren’t likely to spread
outside the breast, endocrine therapy is
advised if the breast tumor is larger than 3 cm
or the lymph node tumor is larger than 2 mm.
• For breast cancers that have a higher chance
of spreading, endocrine therapy is advised
unless there is no cancer in lymph nodes.
• There are 4 main types of endocrine therapy.
Antiestrogens block the action of estrogen.
Aromatase inhibitors, ovarian ablation, and
ovarian suppression lower the amount of
hormones in the body.
• Which regimens for endocrine therapy are
advised is based on menopausal status.
Medicines used for endocrine therapy are
taken for 5 to 10 years.
• Endocrine therapy causes symptoms of