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30

NCCN Guidelines for Patients

®

:

Breast Cancer – Locally Advanced (STAGE III)

Version 1.2017

3

Chemotherapy and HER2 treatment Treatment guide

Treatment guide

Chemotherapy options for breast cancer depend on

HER2 status.

Guide 3

lists the treatment options for

HER2-negative cancers. Guide 4 lists the treatment

options for HER2-positive cancers. Options are

grouped into “preferred” and “other” regimens. These

groups are based on how well the drug works, side

effects, and treatment schedules.

Chemotherapy drugs differ in the way they

work. Thus, more than one drug is often used.

A combination regimen is the use of two or more

cancer drugs.

Chemotherapy is given in cycles of treatment days

followed by days of rest. Likewise, some targeted

therapies are also given in cycles. The cycles vary in

length depending on which drugs are used. Giving

chemotherapy in cycles gives your body a chance to

recover after receiving chemotherapy.

Guide 3. Options for HER2-negative cancers

Preferred regimens

Schedule

Total time

Dose-dense AC

Four 14-day cycles

4 months

then paclitaxel

Four 14-day cycles

Dose-dense AC

Four 14-day cycles

5 months

then weekly paclitaxel

Twelve 7-day cycles

TC

Four 21-day cycles

3 months

Other regimens

Schedule

Total time

Dose-dense AC

Four 14-day cycles

2 months

AC

Four 21-day cycles

3 months

CMF

Six 28-day cycles

6 months

AC

Four 21-day cycles

6 months

then docetaxel

Four 21-day cycles

AC

Four 21-day cycles

6 months

then weekly paclitaxel

Twelve 7-day cycles

EC

Eight 21-day cycles

6 months

TAC

Six 21-day cycles

4 months and 2 weeks

Abbreviations: AC = doxorubicin + cyclophosphamide; CMF = cyclophosphamide + methotrexate + fluorouracil;

EC = epirubicin + cyclophosphamide; TAC = docetaxel + doxorubicin + cyclophosphamide;

TC = docetaxel + cyclophosphamide