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32

NCCN Guidelines for Patients

®

:

Breast Cancer – Locally Advanced (STAGE III)

Version 1.2017

3

Chemotherapy and HER2 treatment What to expect

Guide 4. Options for HER2-positive cancers

Preferred regimens

Schedule

Total time

AC

Four 21-day cycles

1 year and 3

months

then paclitaxel with pertuzumab

and trastuzumab

Four 21-day cycles

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

AC

Four 21-day cycles

1 year and 3

months

then paclitaxel with trastuzumab Twelve 7-day cycles

then trastuzumab

Every 7 or 21 days to complete 1 year on trastuzumab

Dose-dense AC

Four 14-day cycles

1 year and 2

months

then paclitaxel with trastuzumab Four 14-day cycles with weekly trastuzumab

then trastuzumab

Every 7 or 21 days to complete 1 year on trastuzumab

TCH

Six 21-day cycles

1 year

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

TCH + pertuzumab

Six 21-day cycles

1 year

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

Abbreviations: AC = doxorubicin + cyclophosphamide; TCH = docetaxel + carboplatin + trastuzumab