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33

NCCN Guidelines for Patients

®

:

Breast Cancer – Locally Advanced (STAGE III)

Version 1.2017

3

Chemotherapy and HER2 treatment What to expect

Guide 4 continued

Other regimens

Schedule

Total time

AC

Four 21-day cycles

1 year and

3 months

then docetaxel with trastuzumab Four 21-day cycles with weekly trastuzumab

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

AC

Four 21-day cycles

1 year and

3 months

then docetaxel with pertuzumab

and trastuzumab

Four 21-day cycles

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

Docetaxel and cyclophosphamide

with trastuzumab

Four 21-day cycles with trastuzumab every 7 or 21 days

1 year

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

Paclitaxel with trastuzumab

Twelve 7-day cycles with weekly trastuzumab

1 year

then trastuzumab

Every 7 or 21 days to complete 1 year on trastuzumab

FEC

Three 21-day cycles

1 year

then docetaxel with pertuzumab

and trastuzumab

Three 21-day cycles

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

FEC

Three 21-day cycles

1 year

then paclitaxel with pertuzumab

and trastuzumab

Three 21-day cycles

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

Docetaxel with pertuzumab and

trastuzumab

Four 21-day cycles

1 year

then FEC

Three 21-day cycles

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

Paclitaxel with pertuzumab and

trastuzumab

Four 21-day cycles

1 year

then FEC

Three 21-day cycles

then trastuzumab

Every 21 days to complete 1 year on trastuzumab

Abbreviations: AC = doxorubicin + cyclophosphamide; FEC = fluorouracil + epirubicin + cyclophosphamide

TCH = docetaxel + carboplatin + trastuzumab