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53

NCCN Guidelines for Patients

®

:

Breast Cancer – Locally Advanced (STAGE III)

Version 1.2017

6

Endocrine therapy

Overview

Guide 9. Cancer drugs for hormone-related growth

Type

Subtype

Generic name

Brand name

How they work

Antiestrogens

SERD

Fulvestrant

Faslodex

®

Prevent key signals for

cancer cell growth

SERM

Tamoxifen citrate –

Toremifene citrate Fareston

®

Aromatase

inhibitors

Non-steroid

Anastrozole

Arimidex

®

Lower estrogen levels

Letrozole

Femara

®

Steroid

Exemestane

Aromasin

®

Ovarian

suppression

LHRH agonist

Goserelin acetate Zoladex

®

Lower estrogen levels

Leuprolide acetate Lupron Depot

®

Figure 14

Antiestrogens

Antiestrogens are drugs that

stop the effect of estrogen on

cancer cell growth. There are two

types—SERMs and SERDs. Both

block estrogen from attaching

to its receptor and starting cell

growth. SERDs also help to

destroy the receptor.

estrogen

antiestrogen

receptor

cancer cell

Copyright © 2017 National Comprehensive Cancer Network

®

(NCCN

®

).

www.nccn.org

blocks estrogen